Unidox contraindications. Treatment with Unidox Solutab tablets - instructions for use in ureaplasma, composition and analogues. What Unidox Solutab is used for

A modern antibacterial agent from the tetracycline subgroup is Unidox Solutab tablets. What is the benefit of this antibiotic? The drug is able to have a long therapeutic effect, which makes it a popular antibacterial agent. Means "Unidox Solutab" instructions for use recommends for the relief of inflammatory symptoms that accompany many pathologies provoked by pathogens of an infectious nature.

Active ingredients in the composition and form of release

The manufacturer in the instructions "Unidox Solutab" indicates that the main active ingredient of the drug is a representative of the tetracycline subgroup - Doxycycline, in a volume of 0.1 g. It is he who has pronounced anti-inflammatory effects.

Of the auxiliary components are listed: magnesium stearate and microcrystalline cellulose, hyprolose and lactose monohydrate, as well as colloidal silicon dioxide.

Their purpose is to maintain and enhance the impact on the human body of the main pharmacological substance.

In the pharmacy network, the medicinal antibiotic Unidox Solutab, which helps with infectious pathologies, can be purchased in the form of tablets, biconvex, with a yellowish color.

pharmachologic effect

The drug "Unidox Solutab", instructions for use informs about this, is a semi-synthetic tetracycline with a wide range of antibacterial effects - with a bacteriostatic effect. The drug has the ability to inhibit the activity of microorganisms located inside the affected cell. Particularly susceptible to the drug are staphylococci and streptococci, as well as clostridia and Haemophilus influenzae, Klebsiela and Shigella, Enterobacter and most strains of treponema.

The pharmacological agent "Unidox Solutab" is inactive against the fungal flora and many strains of Pseudomonas aeruginosa, as well as Proteus. The instructions also indicate that the drug, compared with other representatives of the tetracycline subgroup, has a more pronounced and lasting effect. There is a high therapeutic activity.

Experts appreciate the drug for its wide range of antibacterial effects. Bacteriostatic effect against not only gram-positive pathogens - clostridia, listeria, staphylococci, but also gram-negative microorganisms - Haemophilus influenzae, Neisseria, Klebsiella or Salmonella, Yersenia, Treponema. The drug is able to act inside the cells of the human body.

There is a practice of using the Unidox Solutab medication, which helps for many indications, against most pathogens of such dangerous infectious pathologies as cholera, brucellosis or chlamydia, psittacosis, legionellosis, venereal granulomas. However, the pharmacological agent does not have the ability to suppress the activity of most strains of Pseudomonas aeruginosa and Proteus. It is absolutely ineffective in the treatment of various fungal infections, therefore, it is not used for the treatment of these diseases.

Unlike other tetracyclines against the background of high therapeutic activity, the drug practically does not inhibit healthy intestinal microflora. Which is very important in the treatment of people with immunodeficiency.

Tablets "Unidox Solutab": what helps and when the medicine is prescribed

Only a specialist should determine the need to use the Unidox Solutab drug - after analyzing the information from diagnostic procedures, the severity of negative symptoms, the age category of the patient, and his susceptibility to the therapy being performed.

The instructions for the medication indicate the following list of indications for taking the medication:

• various ENT pathologies - otitis media, tonsillitis, sinusitis;
• lesions of the pathogenic microflora of the structures of the respiratory system - tracheitis, pharyngitis, acute or chronic form of bronchitis, abscess formation of the lung parenchyma;
• infectious processes in the urinary organs. Eg. Cystitis, prostatitis, pyelonephritis or urethritis, endometritis;
• identified infections of the genital tract - ureaplasmosis, syphilis or gonorrhea, chlamydia;
• inflammatory foci in the structures of the gastrointestinal tract - gastroenterocolitis, cholecystitis, yersineosis, as well as damage to vibrio cholerae;
• the drug has proven itself in the complex treatment of trachoma, sepsis, as well as peritonitis and osteomyelitis.

Why is the drug Unidox Solutab prescribed yet? With the help of the medication, it is possible to cope with such less commonly diagnosed pathologies as yaws and rickettsiosis, legionellosis and Q fever, as well as typhoid and Lyme disease. It is used if the patient is diagnosed with: spotted fever and tularimia, actinomycosis and plague, or malaria and psittacosis, leptospirosis and ornithosis, in addition - bartonellosis and anthrax, whooping cough and brucellosis. It can be used for acne of an unclear, but severe course.

Basic and relative contraindications

Like any pharmacological agent, the medicine "Unitox Solutab", the instructions for use confirm this, there are contraindications for use:

• decompensated states of renal and hepatic structures;
• identified porphyria;
• the period of bearing the baby and its subsequent lactation;
• individual hyperreaction to the main and auxiliary substances of the drug "Unidox Solutab", from which the tablets can cause allergies;
• children's category of patients up to 18 years.

Particular caution is required if the patient has a history of allergic conditions to take any drug from the subgroups of antibiotics with a mechanism of action similar to tetracyclines.

The drug "Unidox Solutab": instructions for use

The instructions for the Unidox Solutab pharmacological agent attached to the package indicate that it is recommended to dissolve the tablets in a small amount of water immediately before taking them - until a suspension is obtained. It is better to drink the resulting solution after a meal. Let's also take a tablet orally without crushing or dissolving it - swallow it and drink it with water. As a rule, the duration of the treatment course is no more than 5-10 days.

For the adult category of patients, as well as for children over 8–9 years old and weighing more than 50–55 kg, the starting dose is 200 mg / day once, less often in 2 doses. Then the dose is 1 pc. once a day.

In infectious lesions with a severe course - a dose of 2 tablets is maintained throughout the treatment course.

For the pediatric category of patients under 9-11 years of age and weighing less than 50-55 kg, the average daily dose is 4 mg / kg on the first day, then 2 mg / kg, in two to three doses. In severe pathologies of an infectious nature, the dose remains equal to 4 mg / kg throughout the course of treatment.

In case of a severe disorder of activity in the hepatic or renal structures, the doses of Unidox Solutab must be adjusted by a specialist.

Unwanted Effects

Of the possible undesirable effects when taking the medication, the instructions list:

• dysphagia;
• enterocolitis;
• hives;
• photosensitivity;
• neutropenia;
• angioedema shock;
• candidiasis.

After discontinuation of the drug, they are completely eliminated.

Analogues of the drug "Unidox Solutab"

Structural analogues containing an identical active substance are:

1. Vidoccin.
2. "Doxylan".
3. "Doxal".
4. Doxycycline Nycomed.
5. "Dovicin".
6. "Basado".
7. "Monoklin".
8. "Doxycycline".
9. "Doxycycline Stada".
10. "Doxycycline hydrochloride".
11. "Doxybene".
12. "Xedocin".
13. "Doxycycline-AKOS".
14. "Vibramycin".

The drug Unidox Solutab contains active ingredient doxycycline- an antibiotic of the tetracycline group. Doxycycline has a bacteriostatic effect due to the inhibition of the synthesis and metabolism of proteins contained in the cell membrane of microorganisms. In addition, the drug disrupts the connection of certain types of RNA with the ribosome membrane. The drug is characterized by a significantly higher activity against cultures of microorganisms that are in the functional stage of growth and division, at the same time, the drug has practically no effect on microorganisms in the dormant stage.

The bacteriostatic effect of the drug extends to a wide range of microorganisms, including:
Gram-positive bacteria: Streptococcus haemolyticus, Streptococcus pneumoniae, Streptococcus viridans, Streptococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Listeria spp., including Listeria monocytogenes.
Gram-negative bacteria: Bacillus anthracis, Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influence, Brucella spp., Clostridium spp., Escherichia coli, Shigella spp., Salmonella spp., Yersinia spp., Vibrio spp., Pasteurella spp., Propionibacterium acnes, Enterobacter spp., Klebsiella spp., Bacteroides spp., Entamoeba histolytica.
Bacteria that cause sexually transmitted infections (STIs): Mycoplasma spp., Chlamydia spp., Rickettsia spp., Spirochaeta spp.
The drug is inactive against Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

A drug Unidox Solutab well absorbed from the gastrointestinal tract when taken orally, food intake practically does not change the degree of absorption of doxycycline. The maximum concentration of the drug in the blood plasma is reached within 2 hours after oral administration of the drug. About 90% of doxycycline is reversibly bound to plasma proteins, the drug penetrates well into tissues, but is practically not detected in the cerebrospinal fluid. The drug is partially metabolized in the body with the formation of active and inactive metabolites. The active metabolites of the drug and doxycycline unchanged are excreted mainly in the urine, inactive metabolites (mainly chelated compounds) are excreted in the feces. The half-life with a single use is 16-18 hours, with repeated administration of the drug, the half-life increases and is about 22-23 hours. In patients with renal insufficiency, the half-life does not change.

The drug is found in high concentrations in the tissues of the prostate gland. Doxycycline crosses the hematoplacental barrier, some doxycycline is excreted in breast milk.

Indications for use

Unidox Solutab is used to treat infectious diseases caused by doxycycline-susceptible microorganisms in adults and children over 8 years of age, including:
- infectious diseases of the upper respiratory tract and respiratory tract;
- infectious diseases of the gastrointestinal tract;
- infectious diseases of the genitourinary system, including gonorrhea, chlamydial infections, urogenital mycoplasmosis, primary and secondary syphilis, pyelonephritis, cystitis, prostatitis;
- infections of soft tissues and skin, including acne;
- typhus.

Mode of application

Doses of the drug and the duration of the course of treatment are determined by the attending physician individually for each patient.

Usually, adults and children weighing more than 50 kg are prescribed on the first day of treatment 200 mg of the drug 1 time per day or 100 mg of the drug 2 times a day. Starting from the second for therapy, the drug is taken in a daily dose of 100 mg.
In severe infectious diseases, 200 mg of the drug is prescribed daily during the entire course of therapy.

Children over 8 years of age weighing less than 50 kg are prescribed at the rate of 4 mg/kg of body weight on the first day of treatment and 2 mg/kg of body weight per day during the entire course of drug treatment. In severe infectious conditions, 4 mg / kg body weight is prescribed 1 time per day during the entire course of therapy.

For the treatment of gonorrhea, women are prescribed 200 mg of the drug daily, the course of treatment is at least 5 days. Men are prescribed 200-300 mg for 2-4 days. Or 300 mg 2 times a day (break between taking tablets 1 hour), the course dose for this treatment regimen is 600 mg.
For the treatment of primary and secondary syphilis, usually 300 mg per day is prescribed. The course of treatment is at least 10 days.
For the treatment of typhus, the drug is taken once at a dose of 100-200 mg.

Tablets Unidox Solutab taken orally as a whole, the tablet can also be divided or crushed, washed down with the drug with the required amount of water. The crushed tablet can also be diluted with water to form a syrup (approximately 20 ml of water) or suspension (up to 100 ml of water).
The dose of the drug is recommended to be taken at a time, unless otherwise prescribed.

Side effects

When using the drug in patients, the following side effects were noted:
From the gastrointestinal tract: nausea, vomiting, loss of appetite, dysphagia, glossitis, stool disorders, enterocolitis.
On the part of the hematopoietic system: hemolytic anemia, thrombocytopenia, eosinophilia, a decrease in the prothrombin index.
From the side of the central nervous system: dizziness, headache, increased intracranial pressure.
From the skin: erythema, dermatitis, photosensitivity.
Allergic reactions: pruritus, rash, urticaria, Quincke's edema, anaphylactic reactions. Perhaps the development of pericarditis and exacerbation of systemic lupus erythematosus.
Other side effects: the development of candidal infections, including vaginitis, glossitis, stomatitis.

Contraindications

- Increased individual sensitivity to the components of the drug and tetracyclines;
- acute and chronic renal and / or liver failure;
- period of pregnancy and lactation;
- children's age up to 8 years.

Pregnancy

The drug is contraindicated for use during pregnancy, since doxycycline can cause impaired bone formation in the fetus.
If it is necessary to use the drug during lactation, it is necessary to resolve the issue of stopping breastfeeding.

Interaction with other drugs

The drug is not prescribed simultaneously with penicillin antibiotics, cephalosporins and other antimicrobial drugs that have a bactericidal effect.
Due to the chemical reaction of doxycycline with metals and antacids, inactive compounds are formed, so the simultaneous administration of these drugs is undesirable.
With the simultaneous use of the drug with anticoagulants, it is necessary to take into account the possibility of changing the prothrombin time.

Overdose

In case of overdose, patients experience nausea, vomiting, dizziness, diarrhea, anorexia, headache.
There is no specific antidote. Shown gastric lavage, intake of enterosorbents, symptomatic treatment.

Release form

Tablets of 10 pieces in a blister, 1 blister in a carton.

Storage conditions

The drug is recommended to be stored in a dry place at a temperature not exceeding 25 degrees Celsius.
Shelf life - 5 years.

Synonyms

Doxycycline

Compound

1 tablet contains:
Doxycycline - 100 mg.
Excipients.

Main settings

Name:	UNIDOX SOLUTAB
ATX code:	J01AA02 -

- a powerful broad-spectrum antibiotic. The drug belongs to the subcategory of tetracyclines, it has a depressing effect on the pathogenic flora. The medicine is used mainly in gynecology, ophthalmology and otolaryngology. With the help of this tool, the prevention of suppuration of wounds in the postoperative period is carried out.

– an effective drug with a wide range of applications

Release form and composition of Unidox

The medication is available in the form of tablets. One package contains ten pieces. The tablets are odorless, have a yellowish coating. The blisters are in lightweight cardboard packaging.

The tablet contains 100 mg of the active ingredient - doxycycline. This substance is a semi-synthetic antibiotic. Doxycycline is effective for the treatment of gram-negative and gram-positive pathogens.

Additional components:

• cellulose;
• sweetener;
• magnesium stearate;
• lactose monohydrate (as a base);
• silicon dioxide (colloidal anhydrous).

The drug contains many chemical elements, so it can cause an allergic reaction in people with hypersensitivity. The tool is manufactured by Astellas.

Unidox Solutab contains the substance doxycycline

Price and analogues of the drug

The average cost of the drug is 350 rubles. On the Internet, you can buy Unidox Solutab a little cheaper – for 310 – 340 rubles. The medicine is also sold in pharmacies, dispensed by prescription.

The main analogues of the drug (products containing doxycycline as an active ingredient):

1. Vidoccin. It is produced in the form of a lyophilizate (means for the preparation of a medicinal suspension). Contraindicated in patients under 8 years of age, pregnant and lactating women. The drug can be drunk or injected with it. The main advantage of the drug is that it can be stored indefinitely. The price of the medication: from 80 rubles.
2. Xedocin. Produced in tablet form. Tablets labeled A6 contain 100 mg of the active substance (per 1 piece). The drug marked A7 has a high content of the active ingredient (200 mg per tablet). The drug is prohibited for use by children, pregnant and lactating women. The tool is not recommended for leukopenia, porphyria and severe liver failure. The cost of the medicine: from 200 rubles.
3. Doxycycline. Available in the form of capsules and lyophilisate. It is not used to treat children under 12 years of age, as well as pregnant and lactating women. 1 capsule contains 100 mg of the active ingredient. The drug is effective for acne and acne. The lyophilisate can be used for the treatment of children over 8 years of age. The cost of the drug: from 30 to 250 rubles (depending on the place of purchase and form of release).

Can Unidox Solutab be used to treat acne? Yes, the drug is able to cure various bacterial rashes. You can look at the before and after photos on the Internet to see for yourself the effectiveness of the product. But keep in mind that this medicine is not suitable for everyone.

Unidox Solutab can cure acne

Indications for the use of Unidox

With the help of the drug, infectious and inflammatory diseases that have arisen against the background of pathogenic microflora are treated. The tool destroys bacteria such as Klebsiella, Salmonella, Staphylococcus aureus.

What helps? General indications for use:

• otolaryngological infections (in particular, sinusitis, tonsillitis, otitis media);
• diseases of the genitourinary system (urethritis, bacterial prostatitis, cystitis);
• diseases of the respiratory system (acute bronchitis, pneumonia, pharyngitis);
• sexually transmitted pathologies (the drug shows high efficiency in ureaplasma, syphilis and chlamydia);
• diseases of the gastrointestinal tract and biliary organs (cholangitis, cholera, amoebic and bacillary dysentery);
• skin infections and soft tissue lesions (particularly severe acne).

The drug Unidox Solutab fights pathogenic microflora

Unidox is part of the complex therapy for infectious eye diseases. The drug is used to treat purulent-necrotic processes occurring in bone tissues. The drug is used to prevent various postoperative complications.

The drug can be used to treat ulcers of various localization. Before use, be sure to consult a doctor.

Pharmacological action of tablets

With prolonged use of the drug, pathogenic microorganisms develop tolerance to the entire group of tetracyclines.

The drug is absorbed by 90 – 95% (average) in 2 hours. Food has no effect on the absorption of the drug, so you can eat before and after taking the medication. Maximum concentration of the active substance in the blood: 2.5 – 3 mg per 1 ml. After 24 hours, the doxycycline level drops to 1.2 – 1.4 mg per 1 ml. The drug is excreted through the kidneys and intestines.

The drug can be taken before and after meals.

Instructions for use Unidox Solutab

The daily dose of the drug depends on the age of the patient, as well as on the type and stage of development of the disease. In hepatic or renal insufficiency, the dosage should be reduced, as there is a risk of excessive stress on these organs. The drug accumulates in the body and has a hepatotoxic effect.

Average duration of therapy – from 5 to 12 days.

Adults and children weighing over 50 kg are prescribed a constant daily dose of 100 mg, on the first day of admission - 200 mg. For advanced and severe infections, the daily dosage throughout the treatment is 200 mg.

Dose for patients from 8 years old weighing up to 50 kg – 4 mg per 1 kg on the first day of therapy, 2 mg per 1 kg on the remaining days. In severe diseases, the stable dosage is 4 mg per 1 kg of body weight.

Application diagram for special cases:

1. With infectious tonsillitis, rheumatism and bilateral kidney damage by a pyogenic bacterium streptococcus pyogenes – 200 mg per day, course of treatment for at least 1.5 weeks.
2. In primary syphilis, the daily dosage is 200 mg, the course of therapy is 2 weeks. With the secondary appearance of the disease, it is necessary to conduct a monthly treatment course with the same dosage.
3. With severe acne lesions, the therapeutic course takes 1 – 2 months with a daily dose of 1 tablet.
4. For the prevention of tropical diseases, 100 mg is prescribed 3 days before departure for vacation. To protect against diarrhea, you should drink 200 mg of the medicine on the day of departure.
5. With a simple gonorrhea (gonorrhea), 600 mg of the drug is prescribed in two divided doses per day. The time interval between doses is 1 hour.

The maximum allowable dose for 1 day for a patient over 18 years of age – 600 mg. The therapeutic course at this dosage should not last longer than 5 days. The maximum allowable dose for a child – 4 mg per 1 kg.

How to use? The agent must be dissolved in 20 – 30 ml of purified warm water. The resulting suspension should be drunk. The drug should not be taken immediately before bedtime. It is advisable to drink it while eating, while in a sitting or standing position.

Unidox Solutab tablet must be dissolved in a glass of water

Contraindications and side effects

Unidox Solutab is strictly contraindicated:

• during pregnancy (the drug slows down the development of bones, negatively affects the formation of teeth in the fetus);
• during lactation (the active substance enters the mother's milk);
• with serious diseases of the kidneys and liver;
• with an increased level of porphyrins in the body;
• for children under eight years of age.

Also, the medication should not be taken by people with hypersensitivity to the components of the composition or tetracyclines. As side effects, allergic reactions may occur: swelling and rashes. If signs of intolerance appear, Unidox is replaced with another drug.

Common side effects:

• nausea and vomiting;
• diarrhea or constipation;
• papular rash;
• change in the shade of the teeth (in children);
• blurred vision, general weakness.

With prolonged therapy, anorexia, darkening of the thyroid tissue may occur. In patients with liver failure, severe lesions of this organ may appear.

When taking the drug, diarrhea may begin.

Drug compatibility

It is not recommended to take the medicine together with antacids at the same time. For the duration of treatment, it is better to abandon hormonal contraceptives, since Unidox reduces the reliability of this method of protection. With a one-time use with Retinol, the patient's intracranial pressure is significantly reduced.

With alcohol

Unidox and alcohol-containing drinks are incompatible with each other. Alcohol doubles the load on the liver, and the effect of the drug reduces to almost zero. The drug accelerates the absorption of the drink and increases the negative impact of alcoholic toxins. When combining the drug and alcohol, the following consequences may occur: hematemesis and diarrhea, fever, chills, dizziness.

In principle, alcohol should not be consumed during antibiotic therapy. Regardless of which medication the person is taking.
Do not take Unidox Solutab with alcohol

With dairy products

While taking antibiotics from the category of tetracyclines, it is strictly forbidden to consume any dairy products (regardless of the age and condition of the patient). Calcium contained in dairy foods reduces the effectiveness of the drug several times. After taking such products, the drug is not completely absorbed.

Antibiotics should also not be combined with carbonated drinks, natural juices and sour dishes (with the addition of vinegar).

During treatment with the drug, it is forbidden to eat any dairy products.

Doxycycline or Unidox Solutab – what's better?

The price of Unidox Solutab is 2.5 times higher than that of Doxycycline. Many people think that the differences between the drugs are insignificant, and choose a cheaper remedy. What actually causes the difference in the cost of medicines?

The Unidox formula allows it to quickly dissolve in water and be completely absorbed into the body. Along with this, the bioavailability of Doxycycline is only 50 – 60%. That is, the drug begins to act in the stomach, which is fraught with negative consequences - pain, spasms. With prolonged use, serious diseases of the digestive system may occur.

The second factor to be taken into account is – This is the effect of drugs on tooth enamel. Unidox can cause yellowing of teeth in children, as their enamel is several times weaker than in adults. After the use of Doxycycline, there is a change in the shade of the teeth in 30 – 40% of patients. Given these factors, Unidox still turns out to be better than Doxycycline, albeit more expensive.

Unidox Solutab is an unusual drug with some fantastic properties. Well? In this article, I tried to collect the most complete information about this tool. Perhaps this collection will be useful to someone.
And most importantly: share your thoughts at the end of the article. Your feedback is the most important thing on our website.

And at the end of the introduction, as always: do not self-medicate and consult a doctor! Treat this offer with due consideration. We don't just write this.

pharmachologic effect

Doxycycline is rapidly absorbed from the gastrointestinal tract and distributed in biological fluids and tissues of internal organs. Once in the focus of inflammation, the active component prevents the synthesis of a special protein that is part of the RNA of the bacterial cell. As a result, the death of pathogenic microflora, which is the causative agent of infection, occurs.

Unidox has a bacteriostatic effect on gram-positive and gram-negative aerobic bacteria. However, such harmful microorganisms as Pseudomonas aeruginosa, Proteus spp., Serratia spp., most strains of Bacteroides fragilis, are not sensitive to the drug.

Interaction with other drugs

The appointment of Unidox Solutab in conjunction with cephalosporins, antibiotic drugs of the penicillin series and other drugs that have a bactericidal effect is contraindicated.

Also, the simultaneous use of doxycycline with antacids and other metal-containing agents is undesirable due to the possibility of the formation of inactive compounds due to a chemical reaction.

It is possible to change the prothrombin index with the combined use of doxycycline with anticoagulants.

Colestipol and cholestyramine reduce the absorption of the drug.

When taken simultaneously with retinol, a significant increase in intracranial pressure is possible.

The drug reduces the effectiveness of oral contraceptives and increases the frequency of uterine bleeding that occurs against the background of their use.

The drug Unidox Solutab instructions for use

The instructions for the Unidox Solutab pharmacological agent attached to the package indicate that it is recommended to dissolve the tablets in a small amount of water immediately before taking them - until a suspension is obtained. It is better to drink the resulting solution after a meal. Let's also take a tablet orally without crushing or dissolving it - swallow it and drink it with water. As a rule, the duration of the treatment course is no more than 5-10 days.

For the adult category of patients, as well as for children over 8–9 years old and weighing more than 50–55 kg, the starting dose is 200 mg / day once, less often in 2 doses. Then the dose is 1 pc. once a day.

In infectious lesions with a severe course - a dose of 2 tablets is maintained throughout the treatment course.

For the pediatric category of patients under 9-11 years of age and weighing less than 50-55 kg, the average daily dose is 4 mg / kg on the first day, then 2 mg / kg, in two to three doses. In severe pathologies of an infectious nature, the dose remains equal to 4 mg / kg throughout the course of treatment.

• therapy for leptospirosis - 1 pc. orally twice a day for 7-8 days, in order to prevent it - 2 pcs. once a week throughout the stay in a dangerous region, as well as 200 mg towards the end of the business trip;
• with an uncomplicated form of gonorrhea, adult patients are prescribed 1 pc. twice a day until a confirmed cure - at least 7-8 days, or the treatment regimen may be different - on the first day of pharmacotherapy, 300 mg in two doses, the second should be 55-60 minutes after the initial dose;
• for acne rashes on the skin 1 piece / day, treatment course 6.5–11.5 weeks;
• for the preventive purpose of the appearance of malaria - 1 piece / day two days before the trip, then every day throughout the stay in the region dangerous for malaria pathology, and another 20-25 days after returning;
• with syphilis of the primary form - 1 pc. 2 r / d, for 14 days, with a secondary form - 1 pc. twice a day, for 28-30 days;
• with pathology provoked by streptococcal flora - the duration of taking the medication is at least 9-10 days;
• with urogenital pathologies of an infectious nature, uncomplicated course - chlamydia, cervicitis, urethritis, provoked by ureaplasma, it is recommended to take 1 pc. medication twice, at least 7-8 days;
• for preventive measures to prevent diarrhea in travelers - 2 pcs. for the first day in two doses, then - 1 pc. once throughout the trip, but no more than 2-4 days;
• to prevent the development of infection after an abortion - 1 tablet an hour before manipulation and 2 pcs. after the surgical intervention;
• maximum doses per day in the treatment of gonococcal pathologies - for the adult category of patients - up to 3 pcs. or 6 pcs. per day for 5 days, for babies over 8–9 years old with a weight above 50–55 kg - 2 pcs. , for children weighing no more than 50 kg - 4 mg / kg per day throughout the pharmacotherapy.

In case of a severe disorder of activity in the hepatic or renal structures, the doses of Unidox Solutab must be adjusted by a specialist.

special instructions

To prevent the occurrence of dyspeptic disorders, Unidox Solutab is recommended to be taken with meals.

There is a possibility of developing cross-resistance and hypersensitivity with other tetracycline drugs.

With long-term treatment, it is necessary to regularly monitor the functions of the kidneys and liver, laboratory blood counts.

Prolonged use of Unidox Solutab can lead to dysbacteriosis and, as a result, hypovitaminosis, especially vitamins of group B.

Given the risk of developing photodermatitis, during the entire period of treatment and 4-5 days after its completion, insolation should be limited.

Unidox Solutab may increase prothrombin time and should therefore be used with extreme caution in patients with coagulopathy. . Due to the anti-anabolic effect, an increase in the level of residual urea nitrogen in the blood is possible

For patients with normal renal function, this phenomenon is usually of no clinical significance. However, in renal insufficiency, this can lead to an increase in azotemia. For this reason, in patients with functional impairment of the kidneys, Unidox Solutab should be used under close medical supervision.

Due to the anti-anabolic effect, an increase in the level of residual urea nitrogen in the blood is possible. For patients with normal renal function, this phenomenon is usually of no clinical significance. However, in renal insufficiency, this can lead to an increase in azotemia. For this reason, in patients with functional impairment of the kidneys, Unidox Solutab should be used under close medical supervision.

Influence on the ability to drive vehicles and complex mechanisms

The effect of doxycycline on human cognitive and psychophysical functions has not been studied. There are known cases of dizziness, double vision, blurred vision during treatment. Such patients are advised to refrain from driving and performing potentially hazardous activities while taking Unidox Solutab.

Composition and dosage forms

The composition of the drug includes an active semi-synthetic component called doxycycline monohydrate. It performs the main therapeutic function. Other active substances play a supporting role and do not have an antibacterial effect.

Unidox is available in the form of dispersible tablets. They are completely soluble in water.

The drug can be used both in the form of a solution for injections, and in the form of a suspension. The tablets are yellowish-gray in color and round in shape. On one side, the unit of the drug is divided by a risk, on the other, the code 173 is applied. Each Unidox tablet contains 100 mg of doxycycline.

Analogues Unidox Solutab

Coincidence in the ATX code of the 4th level:

• Vibramycin
• doxycycline hydrochloride
• Doxycycline
• Olethetrin

The most common analogues: Vibramycin D, Doxibene, doxycycline hydrochloride, tetracycline hydrochloride, Doxa-M-Ratiopharm, Doxycycline, Tygacil. The price of analogs differs significantly from the original, most often it is lower.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not affect the stomach so much and does not cause side effects characteristic of doxycycline ( stomach ulcer, gastritis ). Absorption of the active substance occurs in the intestine and almost 100% of the drug is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

What is the difference between Unidox and Unidox Solutab?

Console " solyutab” in the name of the drug means that the tablet can be crushed and dissolved in water, prepared suspension for the reception. This way of using the medicine is preferable for children.

In no case do not self-medicate, because it can go sideways for you. Only a doctor can prescribe treatment for you. Remember that acne can be a symptom of a serious illness, and if you don't see a doctor, you don't know what it could turn into for you.

Unidox is an antibiotic. Accordingly, it is strictly forbidden to drink alcohol during treatment. Some people do not stop, and they take risks. You shouldn't do that, because you can't buy health.

A common cause of acne is poor hygiene. To get rid of them once and for all, remember that you need to take a shower every day. It is necessary to wash your face 2 times a day - in the morning and in the evening, and always with cold water.

Analyze your diet. Perhaps it contains such harmful products as chips, fast food, flour, instant noodles, beer and carbonated drinks. Most often, this is the reason. Replace all drinks with water, eat more meat and vegetables. Unnatural products and bad habits should be abandoned. After that, you will find that acne will be much less.

Quite often, the cause of acne and acne on the face is constant stress. There are situations when a person eats normally and follows the rules of hygiene, but this does not save his face from acne. In such a situation, it is necessary to recall all the events of the past few weeks. What were the events that irritated you and spoiled your mood? Your job is to rid yourself of them.

If you find several pimples on your face, you should not constantly think about them. Many life situations obey the laws of meanness. For example, a teenager noticed several pimples on his face. He anointed them with some ointment and forgot. After a few days, the pimples disappeared. And another teenager, after discovering acne, began to worry a lot. He began to fight with them and constantly look in the mirror, hoping that they would not be. In such situations, it is very difficult to get rid of acne. Therefore, if you find this problem, you should not worry, because everything is solvable.

Let's sum it up. In order for acne not to appear, it is enough to lead a healthy lifestyle, follow the rules of hygiene and constantly be in a good mood. If you find acne, do not worry. Try some ointment or go to a beautician. If all this does not help, see a doctor. Most likely, he will prescribe Unidox for you.

Unidox Solutab indications for use

The drug Unidox Solutab is prescribed for treatment to those patients who suffer from infectious and inflammatory diseases that are caused by those microorganisms that are sensitive to the effects of the drug.

Infectious diseases of the respiratory tract

• treatment of pharyngitis;
• pleural empyema;
• acute bronchitis;
• lung abscess;
• obstructive pulmonary disease in the acute stage;
• tracheitis;
• community-acquired pneumonia;
• lobar pneumonia;
• bronchopneumonia.

Infectious diseases of the ENT organs

• treatment of otitis;
• tonsillitis;
• sinusitis.

Diseases of the genitourinary system of an infectious nature

• treatment of cystitis;
• endometritis, salpingoophoritis and endocercevit in combination with other medicines;
• pyelonephritis;
• bacterial prostatitis;
• orchiepididymitis in acute form;
• urethritis;
• mycoplasmosis urogenital;
• urethrocystitis.

Infectious diseases that are sexually transmitted

• treatment of chlamydia urogenital;
• venereal lymphogranuloma;
• syphilis in those patients who do not tolerate penicillin;
• inguinal granulomas;
• gonorrhea uncomplicated.

Infectious diseases of the biliary tract and digestive tract

• treatment of traveler's diarrhea;
• cholera;
• amoebic or bacillary dysentery;
• yersiniosis;
• gastroenterocolitis;
• cholangitis;
• cholecystitis.

Skin infections

• treatment of wound infections as a consequence of an animal bite;
• severe acne as a component of combined therapy.

Eye infections

• treatment of trachoma in combination with other medicines.

Other infectious and inflammatory diseases

• yaws treatment;
• brucellosis;
• legionellosis;
• whooping cough;
• chlamydia;
• erchiliosis granulocytic;
• rickettsiosis;
• bartonellosis;
• Q fever;
• spotted fever of the Rocky Mountains;
• bartonellosis;
• typhus;
• Lyme disease;
• anthrax;
• tularemia;
• ornithosis;
• plague;
• psittacosis;
• actinomycosis;
• leptospirosis;
• malaria;
• osteomyelitis;
• peritonitis;
• septic subacute endocarditis;
• sepsis.

Contraindications

There are also contraindications to the appointment, therefore, when considering the option of treating a particular disease with the participation of this drug, attention should be paid to them. Unidox Solutab should not be prescribed:. in case of violations of the functionality of the kidneys or liver in a severe form in the patient;
porphyria;
pregnancy and feeding;
children under eight years of age.

• in case of violations of the functionality of the kidneys or liver in a severe form in the patient;
• with a high level of hypersensitivity to antibiotics of this group;
• porphyria;
• pregnancy and feeding;
• children under eight years of age.

Unidox's analogs

According to the structure, analogues are determined:

1. Vibramycin.
2. Doksal.
3. Doxycycline hydrochloride.
4. Doxycycline Nycomed (Stada, -AKOS).
5. Monoclin.
6. Bassado.
7. Doksibene.
8. Doxilan.
9. Dovicin.
10. Xedocin.
11. Vidoccin.

What is the difference between Unidox and Unidox Solutab?

The prefix "solutab" in the name of the drug means that the tablet can be crushed and dissolved in water, to prepare a suspension for administration. This way of using the medicine is preferable for children.

Doxycycline or Unidox Solutab - which is better?

The main difference between the drugs is the fact that Unidox does not affect the stomach so much and does not cause side effects characteristic of doxycycline (stomach ulcer, gastritis). Absorption of the active substance occurs in the intestine and almost 100% of the drug is absorbed by the body. The only advantage of doxycycline is its extremely low cost compared to the original.

Antibiotic Unidox Solutab

Reviews of users of this drug speak of its high efficiency. The product is released in the form of large yellow tablets, arranged on a blister in two rows of five pieces.

Indications for use

This drug successfully treats infectious and inflammatory diseases of various organs..

• Gastrointestinal infections: cholecystitis, dysentery, cholera and others.
• Eye infections.
• Peritonitis.
• Sepsis.
• Rosacea.
• Skin diseases and animal bites.
• Cystitis, urethritis, bacterial prostatitis and other diseases caused by infection of the genitourinary system.
• Perfectly copes with diseases of the respiratory tract: bronchitis and pleurisy.

How to take the antibiotic Unidox Solutab

The instruction of this drug advises taking it for five or ten days. The tablet can be swallowed whole, chewed or dissolved in water. Children over eight years of age are given two hundred milligrams of antibiotic per day.

For adults, the dosage regimen is calculated based on the weight of the patient..

So, one kilogram will require four milligrams of funds, and after three days the rate is reduced to two.

Contraindications for use

It is forbidden to take an antibiotic in the following cases:

• Children up to eight years old.
• With renal and hepatic insufficiency.
• Do not prescribe the drug to pregnant women and nursing mothers.
• In case of resistance of the organism to the active substance of the drug, the drug is stopped.

Side effects

In people with renal insufficiency, an increased content of urea nitrogen in the blood can be observed. Such patients should be careful and constantly be under medical supervision.

pharmachologic effect

The drug contains the active substance - doxycycline - an antibiotic of the tetracycline group. Doxycycline has a bacteriostatic effect due to the inhibition of the synthesis and metabolism of proteins contained in the cell membrane of microorganisms.

In addition, the drug disrupts the connection of certain types of RNA with the ribosome membrane. The drug is characterized by a significantly higher activity against cultures of microorganisms that are in the functional stage of growth and division, at the same time, the drug has practically no effect on microorganisms in the dormant stage.

Unidox Solutab instructions for use

The drug can be taken in various ways: dissolve in a small amount of water in order to obtain a suspension, swallow, divide in parts or chew, accompanied by drinking. It is advisable to take the medicine, combining with food at least two hours before bedtime.

The duration of therapy is not more than ten days.

For adult patients and children after reaching eight years of age, whose body weight exceeds fifty kilograms, is prescribed on the first day of treatment at 200 milligrams per day in one or two doses, then 100 milligrams per day once. When the infection is severe, 200 milligrams per day can be used daily.

When the body weight of a child older than eight years does not reach 50 kilograms, the drug is prescribed at an average daily dose of 4 milligrams per kilogram of weight on the first day of treatment and then 2 milligrams per kilogram of body weight per day. In severe infections, you can use the dosage of the first day daily.

streptococcal infection

Treatment lasts up to ten days.

Gonorrhea uncomplicated

Adults: 100 milligrams twice a day for a week or for one day of treatment, 300 milligrams twice a day. The second dose should be taken one hour after the first.

Syphilis primary

100 milligrams twice a day for two weeks.

Syphilis secondary

100 milligrams twice a day for four weeks.

Uncomplicated urogenital infections

100 milligrams 2 times a day for a week of admission.

Acne

100 milligrams for one day. The duration of admission is from 6 to 12 weeks.

Leptospirosis (treatment)

100 milligrams 2 times a day for a week.

Prevention

• malaria: 100 mg. per day a day or two before the start of the trip, directly during the trip every day and within a month after its completion. Children after 8 years: 2 mg/kg of body weight per day. Taking the drug prophylactically should not exceed four months.
• travelers diarrhea: 200 mg. on the first day of travel and then 100 mg. all other days. Reception to carry out no more than three weeks.
• leptospirosis: 200 mg. once a week for the entire period of stay in an area with an unfavorable situation regarding this infection and then at the end of the stay another 200 mg.
• infection during medical abortion: 100 mg. an hour before the procedure and 200 mg. upon its completion.

The maximum allowable daily dose of the drug

For an adult patient: 300 milligrams;

For a child after 8 years (body weight over 50 kg.): 200 milligrams;

For a child after 8-12 years (body weight less than 50 kg.): 4 mg / kg.

For patients suffering from renal insufficiency, it is necessary to reduce the dose of the drug.

Unidox Solutab during pregnancy

During pregnancy, Unidox Solutab is contraindicated. However, with an urgent need to treat a woman, his appointment takes place.

It should be taken into account that doxycycline as the active substance of the drug can have a very adverse effect on the development of the fetus. Therefore, by the time of the appointment of treatment, pregnancy is desirable to exclude.

Breastfeeding is prohibited due to the penetration of doxycycline into a woman's milk.

Unidox Solutab for children

Side effects

When using the drug, the following adverse reactions may develop:

1. Manifestations of allergic reactions: urticaria, anaphylactic reactions, exacerbation of systemic lupus erythematosus, angioedema, pericarditis, erythema multiforme.
2. Manifestations from the nervous system when using Unidox Solutab: increased intracranial pressure (headache, vomiting, swelling of the optic nerve), vestibular changes (dizziness), blurred vision, double vision.
3. Skin manifestations: exfoliative dermatitis, photosensitivity, maculopapular and erythematous rash.
4. Manifestations from the circulatory system: hemolytic anemia, decreased prothrombin activity, thrombocytopenia, neutropenia, eosinophilia.
5. Manifestations from the endocrine system: in patients who have received doxycycline for a long time, reversible staining of the thyroid tissue in a dark brown color may occur.
6. Gastrointestinal manifestations: nausea, vomiting, diarrhea, dysphagia, anorexia, enterocolitis, esophageal ulcer, pseudomembranous colitis, esophagitis, darkening of the tongue, liver damage (with prolonged use or in patients with renal and hepatic insufficiency), cholestasis.
7. Manifestations from the urinary system: increased residual urea nitrogen (as a result of antianabolic action).
8. Manifestations from the musculoskeletal system: doxycycline disrupts the normal formation of teeth in children, irreversibly changing the shade of the teeth (enamel hypoplasia appears).

Other manifestations when using Unidox Solutab: causes candidiasis (stomatitis, proctitis, vaginitis) as a superinfection.

Causes of acne

Pimples are the result of a skin disease. As a rule, the functioning of the sebaceous glands in a certain area of ​​\u200b\u200bthe skin is disturbed. There could be many reasons for this:

1. Violation of hygiene rules.
2. Wrong nutrition.
3. Diseases of the internal organs. The appearance of acne in a certain area of ​​\u200b\u200bthe face indicates a disease of a certain internal organ. For example, a pimple on the forehead indicates diseases of the small intestine.
4. Reaction to cosmetics.
5. Predisposition to acne.
6. Reaction to certain medications.

Many people try to get rid of acne with various ointments and creams. This can help if you have skin problems. However, most often the reason is quite different. Therefore, it is necessary to get rid of it, then the acne will disappear.

This can be done with the help of various drugs, of which there are a lot. Let's talk about one of the most effective acne medications - about Unidox Solutab.

Side effects

Effects that qualify as side effects from taking Unidox Solutab affect various body systems.

Digestive system

Patients complain of the development of dysphagia, vomiting and nausea, diarrhea, anorexia, pseudomembranous colitis, enterocolitis, esophageal ulcers, esophagitis, cholestasis, and dark staining of the tongue. When long-term treatment takes place, it is possible that the liver will be affected. This is especially true for patients with hepatic or renal insufficiency.

Dermatology

In the form of photosensitivity, as well as the development of exfoliative dermatitis and erythematous or maculo-papular rash.

Allergy

Possible reactions in the form of urticaria, erythema multiforme, angioedema, anaphylactic reactions, pericarditis, a syndrome similar to serum sickness and systemic lupus erythematosus in the form of an exacerbation.

hematopoiesis

Perhaps the development of hemolytic anemia, eosinophilia, neutropenia, thrombocytopenia and a decrease in prothrombin activity.

endocrine system

In those patients who have taken the drug for a long time, the tissue of the thyroid gland may stain with a dark brown color. This phenomenon is reversible.

nervous system

There were complaints of double vision and visual blurring. Dizziness also occurred, and vestibular disorders increased HF pressure.

Urinary system

In the form of increases in residual nitrogen in urea.

Muscle and bone system

Osteogenesis slows down, normal dental development in children is disturbed in the form of enamel hypoplasia and changes in their color.

In the form of manifestations of superinfection: candidiasis, vaginitis, glossitis, proctitis, stomatitis.

Overdose

Symptoms of an overdose of the drug are those side effects that will increase with a detrimental effect on the liver. They will manifest themselves in the form of fever, vomiting, azotemia, jaundice, increased levels of transaminases and prothrombin time.

The patient should be treated with immediate gastric lavage and initiation of vomiting after heavy drinking. Activated charcoal and osmotic laxatives are prescribed. Conducting hemodialysis and peritoneal dialysis is not effective.

Drug Interactions

While taking doxycycline with various medications, the following effects may be observed:

• combination with antacids containing magnesium, calcium, aluminum, as well as iron preparations, sodium bicarbonate and magnesium-containing laxatives can reduce the absorption of doxycycline. Therefore, they are taken with a break of at least three hours.
• The dosage of indirect anticoagulants will require adjustment, since doxycycline suppresses the intestinal microflora, which in turn leads to a decrease in the prothrombin index.
• The effectiveness of bactericidal antibiotics is reduced.
• The reliability of contraceptives that contain estrogen hormones is markedly reduced and the risk of acyclic bleeding increases.
• The concentration in the blood plasma of doxycycline will be reduced when combined with ethanol, barbiturates, carbamazepine, phenytoin, rifampicin.
• Retinol together with doxycycline affects the increase in intracranial pressure.

Additional instructions

In connection with the possibility of influencing the prothrombin time, the administration of the drug to those patients who suffer from coagulopathy should be carefully monitored.

It is necessary to control the drug intake in patients with impaired renal functionality in order to avoid an increase in azotemia.

Long-term treatment with the drug leads to the need to control blood laboratory parameters and the functionality of the kidney and liver.

To avoid negative consequences, it is necessary to warn the patient about limiting exposure to the sun in the initial period of treatment.

With the development of diarrhea during treatment with Unidox Solutab, the drug should be discontinued, followed by the appointment of ion-exchange resins. In particularly difficult situations, it is necessary to compensate for the loss of fluid, proteins and electrolytes by the body and prescribe the drugs vancomycin and metronidazole.

You should not combine treatment with taking drugs that have an effect of inhibition on intestinal motility.

Long-term treatment is fraught with dysbacteriosis.

To reduce the likelihood of occurrence of dyspeptic phenomena, it is necessary to take the medication during meals.

With the development of side effects in the form of dizziness, double vision and blurred vision, the patient should not drive a vehicle or carry out other activities related to technical means.

Side effects

• from the side of the cardiovascular system: pericarditis;
• from the gastrointestinal tract: dark staining of the tongue, dysphagia, nausea, esophagitis, diarrhea, vomiting, anorexia, esophageal ulcer, anal itching; with prolonged use of Unidox solutab - deficiency of B vitamins;
• on the part of the kidneys: an increase in residual urea nitrogen; in patients with renal insufficiency - exacerbation of azotemia; in the case of the use of products containing citric acid, symptoms similar to Fanconi's syndrome, such as hypokalemia, hypophosphatemia, glucosuria, albuminuria, renal tubular acidosis;
• on the part of the liver: cholestasis; with renal / hepatic insufficiency or long-term use of Unidox solutab - liver damage, sometimes associated with pancreatitis;
• on the part of the thyroid gland: with prolonged use of Unidox solutab - reversible dark brown staining of the thyroid tissue (in most cases it is not accompanied by functional impairment);
• from the musculoskeletal system: myalgia, arthralgia;
• from the hematopoietic system: eosinophilia, neutropenia, thrombocytopenia, hemolytic anemia, decreased prothrombin activity;
• from the nervous system: double vision, scotoma, blurred vision, hallucinations, vestibular disorders (dizziness or unsteadiness), benign increase in intracranial pressure (optic nerve edema, tinnitus, headache, tremor, vomiting, anorexia);
• on the part of teeth and bones: slowing down of osteogenesis, disruption of the normal development of teeth in children (irreversible discoloration of tooth enamel, development of enamel hypoplasia);
• on the part of the skin: exfoliative dermatitis, photosensitivity, erythematous and maculopapular rash, urticaria, anaphylactic reactions, angioedema, photoonycholysis, Shenlein-Genoch purpura;
• allergic reactions: a syndrome similar to serum sickness, exacerbation of systemic lupus erythematosus, drug rash with eosinophilia and systemic symptoms (dress syndrome), erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, tachycardia, lowering blood pressure;
• others: the development of superinfection (may be manifested by symptoms such as stomatitis, glossitis, candidiasis, pseudomembranous colitis, staphylococcal enterocolitis, vaginitis, anogenital candidiasis).

Side effects

Like any other drug, Unidox has side effects. Their occurrence depends on the individual tolerability of the drug and the joint intake with other drugs.

The stomach and intestines may not respond well to the drug. This may cause the following side effects:

1. Pain.
2. Increased gas formation.
3. Vomiting and nausea.
4. Loss of appetite.
5. Constipation.

Various allergic reactions are possible:

1. Rash.
2. Edema on the face.

These allergic reactions are short lived. If you have them, you need to see a doctor so that he can prescribe you another medicine.

When taking Unidox in children, it can change the color of the teeth, and in adults, intestinal dysbacteriosis develops. After acne treatment, it is necessary to get rid of dysbacteriosis. To do this, it is necessary to conduct a course of treatment with Linex forte.

Unidox can be used not only in tablets, but also in droppers. With intravenous administration of this drug, the maximum daily dose is 300 milligrams.

pharmachologic effect

Pharmacodynamics.

The antibiotic is a long-acting broad-spectrum tetracycline.

It acts bacteriostatically, inhibits protein synthesis in a microbial cell by interacting with the 30S subunit of ribosomes.

Active against gram-positive and gram-negative aerobic and anaerobic bacteria:

• Streptococcus spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including Enterobacter aerugenes), Neisseria gonorrhoeae, Neisseria meningitidis, Haemophilus influenzae, Chlamydia spp., Mycoplasma spp., Ureaplasma urealyticum, Listeria monocytogenes, Rickettsia spp., Escherichia coli, Shigella spp., Campylobacter fetus, Vibrio cholerae, Yersinia spp . (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, Treponema spp., Typhus exanthematicus; some protozoa: Entamoeba spp., Plasmodium falciparum.

As a rule, it is not active against Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.

The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-group within a group (i.e. strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines)

Pharmacokinetics.

Suction.

Absorption is fast and high (100%).

Food intake slightly affects the absorption of the drug, which has no clinical significance.

The maximum concentration of doxycycline in the blood plasma (2.6-3 μg / ml) is reached 2 hours after taking 200 mg, after 24 hours the concentration of the active substance in the blood plasma decreases to 1.5 μg / ml.

After taking 200 mg on the first day of treatment and 100 mg per day on subsequent days, the concentration of doxycycline in the blood plasma is 1.5-3 μg / ml.

Distribution.

Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into tissues, poorly into the cerebrospinal fluid (10-20% of the plasma concentration), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane.

The volume of distribution is 1.58 l / kg.

30-45 minutes after oral administration, doxycycline is found at therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissues, in pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluid.

With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.

In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.

Doxycycline crosses the placental barrier and is secreted in small amounts into breast milk.

Accumulates in dentin and bone tissue.

Metabolism.

Only a small part of doxycycline is metabolized.

Withdrawal.

The elimination half-life after a single oral dose is 16-18 hours, after repeated doses - 22-23 hours.

Approximately 40% of the dose taken is excreted in a biologically active form by tubular secretion in the kidneys, 20-40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations.

The half-life of doxycycline in patients with impaired renal function does not change, because. its excretion through the intestine increases.

Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in plasma.

Interaction with other drugs

1. Magnesium sulfate.
2. potassium chloride.
3. Magnesium sulfate.
4. Collargol.
5. Xeroform.
6. Protargol.
7. zinc sulfate.

We have named the most prescribed drugs for you. Naturally, their list is much longer.

You can not combine Unidox with its antagonists that have a bactericidal effect:

1. Sumamed.
2. Amoxicillin.
3. Ospamox.
4. Cephalexin.
5. Zinnat.
6. Azithromycin.

Drugs such as Colestyramine and Colestipol reduce the absorption of Unidox by the body. To avoid this, it is necessary to maintain an interval of three hours between taking these two drugs.

After treatment with Unidox, the intestinal microflora will be disturbed. To restore it, you need to use Linex.

With extreme caution, you can use Unidox in conjunction with retinol. Of course, this will increase intracranial pressure. This is not so scary for a young organism.

But for older people, it's better not to risk it.

Unidox Solutab tablets from what it helps and when the medicine is prescribed

Only a specialist should determine the need to use the Unidox Solutab drug - after analyzing the information from diagnostic procedures, the severity of negative symptoms, the age category of the patient, and his susceptibility to the therapy being performed.

The instructions for the medication indicate the following list of indications for taking the medication:

• various ENT pathologies - otitis media, tonsillitis, sinusitis;
• lesions of the pathogenic microflora of the structures of the respiratory system - tracheitis, pharyngitis, acute or chronic form of bronchitis, abscess formation of the lung parenchyma;
• infectious processes in the urinary organs. Eg. Cystitis, prostatitis, pyelonephritis or urethritis, endometritis;
• identified infections of the genital tract - ureaplasmosis, syphilis or gonorrhea, chlamydia;
• inflammatory foci in the structures of the gastrointestinal tract - gastroenterocolitis, cholecystitis, yersineosis, as well as damage to vibrio cholerae;
• the drug has proven itself in the complex treatment of trachoma, sepsis, as well as peritonitis and osteomyelitis.

Why is the drug Unidox Solutab prescribed yet? With the help of the medication, it is possible to cope with such less commonly diagnosed pathologies as yaws and rickettsiosis, legionellosis and Q fever, as well as typhoid and Lyme disease. It is used if the patient is diagnosed with: spotted fever and tularimia, actinomycosis and plague, or malaria and psittacosis, leptospirosis and ornithosis, in addition - bartonellosis and anthrax, whooping cough and brucellosis. It can be used for acne of an unclear, but severe course.

Applications and doses

For the fastest and most effective achievement of therapeutic goals, it is recommended to draw up the average daily dosages and the medication regimen together with the attending physician.

The tablets can be taken whole or crushed. Drink the product with plenty of clean water.

for adults

Adult patients and children over 8 years old, whose body weight exceeds 50 kg, are prescribed the initial dose of Unidox Solutab at a dosage of 100 mg 2 times a day or 200 mg 1 time per day. From the second day until the end of the course, the average daily dose should be 100 mg. In severe types of diseases, the initial dosage remains unchanged.

for children

The use of the drug for children under 8 years of age is strictly contraindicated.

The age group over 8 years old, with a body weight of not more than 50 kg, is recommended to take the medication in the following dosages:

• on the first day, the dose of doxycycline should be 4 mg per kg of the child's weight;
• the following doses of medication are 2 mg per kg of body weight.

In case of severe infectious pathologies, the initial dosage does not change throughout the entire therapeutic course.

for pregnant women and during lactation

Pregnant and lactating women are contraindicated in the use of this medication. If necessary, use during the GV period, you should immediately stop breastfeeding the baby.

Dosage

The volume of the drug necessary to fight the infection is determined by the attending physician, depending on the course of the disease, health, age and comorbidities of the patient.

With prostatitis

The defeat of the prostate gland in men requires individual therapy. But most often prescribed 200 mg of the antibiotic on the first day and 100 mg on the following days. The course of treatment lasts from 5 days.

With prostatitis, Unidox is prescribed 200 mg of an antibiotic on the first day.

With ureaplasma

If a woman has ureaplasma, the doctor in most cases prescribes Unidox. An antibiotic with a dosage of 100 mg is taken 2 times a day on the first day, then the volume of the drug is reduced to 1 tablet per 24 hours.

The course of treatment lasts from 10 to 14 days.

If ureaplasmosis is severe, the dosage of the antibiotic may be increased after consulting a doctor.

With chlamydia

Chlamydia is effectively treated with Unidox, since the pathogen is sensitive to tetracyclines. Patients with this diagnosis are prescribed 100 mg of the drug 2 times a day for 7-10 days.

With cystitis

Uncomplicated cystitis does not require an increase in the standard antibiotic dosage. It is recommended to drink 200 mg of the drug at the beginning of the course of therapy, dividing this volume into 2 doses. In the following days - 100 mg 1 time per day. The duration of the use of Unidox is determined by the doctor.

With borreliosis, an infectious disease specialist may prescribe 100-200 mg of doxycycline 2 times a day.

With borreliosis

Such a serious disease as borreliosis, which occurs after tick bites, requires immediate antibiotic therapy. In this case, the infectious disease specialist may prescribe 100-200 mg of doxycycline 2 times a day for 20 days. The maximum daily dose for severe disease is 500 mg.

Other names and classification

The pharmaceutical agent belongs to the class of antibiotics. A drug with a similar effect and composition may have different names that indicate the main active ingredient, manufacturer or individual properties of the drug.

Unidox is used to treat various infectious diseases.

International non-proprietary name INN

In medical circles around the world, this pharmaceutical product is defined as Doxycycline. The generic name is given by the main active ingredient that is part of the drug.

Tradename

The trade name of the drug is Unidox Solutab. Under this definition, the specified antibiotic is sold in pharmacies.

Latin name

In the prescription, the doctor always indicates the Latin name - Unidox Solutab.

ATX

The drug belongs to antimicrobial agents of systemic exposure, antibiotics of the tetracycline series.

Unidox is assigned the ATX code J01AA02.

Unidox Solutab: effectiveness, complications, features of administration, analogues
Unidox Solutab | analogues

Instruction
(information for specialists)
According to the medical use of the drug
UNIDOX SOLUTAB ®
(UNIDOX SOLUTAB®)

Registration number: P N013102/01

Tradename: Unidox Solutab ®

INN: Doxycycline

Dosage form: Dispersible tablets

Compound:
Active substance: doxycycline monohydrate 100.0 mg in terms of doxycycline
Excipients: microcrystalline cellulose, saccharin, hyprolose (low-substituted), hypromellose, colloidal silicon dioxide (anhydrous), magnesium stearate, lactose monohydrate

Description:
Light yellow to grey-yellow, round, biconvex tablets, debossed with "173" (tablet code) on one side and a notch on the other.

Pharmacotherapeutic group: Antibiotic - tetracycline

ATX code:

Pharmachologic effect:
Pharmacodynamics
A broad-spectrum antibiotic from the tetracycline group. It acts bacteriostatically, inhibits protein synthesis in a microbial cell by interacting with the 30S subunit of ribosomes. Active against many gram-positive and gram-negative microorganisms: Streptococcus spp., Treponema spp., Staphylococcus spp., Klebsiella spp., Enterobacter spp. (including E. AERGEGENES), Neisseria gonorrhoeae, neisseria meningitidis, haemophilus influenzae, chlamydia spp., Mycoplasma spp., ureaplasma urealyticum, listeria monocytogenes, ricket TSIA spp., Typhus Exanthematicus, Escherichia Coli, Shigella Spp., Campylobacter Fetus, Vibrio Cholerae, Yersinia spp. (including Yersinia pestis), Brucella spp., Francisella tularensis, Bacillus anthracis, Bartonella bacilliformis, Pasteurella multocida, Borrelia recurrentis, Clostridium spp. (except Clostridium difficile), Actinomyces spp., Fusobacterium fusiforme, Calymmatobacterium granulomatosis, Propionibacterium acnes, some protozoa (Entamoeba spp., Plasmodium falciparum).
Generally does not apply to Acinetobacter spp., Proteus spp., Pseudomonas spp., Serratia spp., Providencia spp., Enterococcus spp.
The possibility of acquired resistance to doxycycline in a number of pathogens should be taken into account, which is often cross-group within a group (i.e. strains resistant to doxycycline will simultaneously be resistant to the entire group of tetracyclines).

Pharmacokinetics
Suction
Absorption - fast and high (about 100%). Eating slightly affects the absorption of the drug.
The maximum level of doxycycline in the blood plasma (2.6-3 μg / ml) is reached 2 hours after taking 200 mg, after 24 hours the concentration of the active substance in the blood plasma decreases to 1.5 μg / ml.
After taking 200 mg on the first day of treatment and 100 mg per day on subsequent days, the plasma concentration of doxycycline is 1.5-3 μg / ml.

Distribution
Doxycycline binds reversibly to plasma proteins (80-90%), penetrates well into organs and tissues, poorly into the cerebrospinal fluid (10-20% of the level in the blood plasma), however, the concentration of doxycycline in the cerebrospinal fluid increases with inflammation of the spinal membrane.
The volume of distribution is 1.58 l/kg. 30-45 minutes after ingestion, doxycycline is found at therapeutic concentrations in the liver, kidneys, lungs, spleen, bones, teeth, prostate gland, eye tissues, in pleural and ascitic fluids, bile, synovial exudate, exudate of the maxillary and frontal sinuses, in gingival sulcus fluid.
With normal liver function, the level of the drug in bile is 5-10 times higher than in plasma.
In saliva, 5-27% of the concentration of doxycycline in blood plasma is determined.
Doxycycline crosses the placental barrier and is secreted in small amounts into breast milk.
Accumulates in dentin and bone tissue.

Metabolism
A small part of doxycycline is metabolized.

breeding
The elimination half-life after a single oral dose is 16-18 hours, after repeated doses - 22-23 hours.
Approximately 40% of the drug taken is excreted by the kidneys and 20-40% is excreted through the intestines in the form of inactive forms (chelates).

Pharmacokinetics in special clinical situations
The half-life of the drug in patients with impaired renal function does not change, because. its excretion through the intestine increases.
Hemodialysis and peritoneal dialysis do not affect the concentration of doxycycline in plasma.

Indications for use
Infectious and inflammatory diseases caused by sensitive
to the preparation with microorganisms:

• respiratory tract infections, including pharyngitis, acute bronchitis, exacerbation of chronic obstructive pulmonary disease, tracheitis, bronchopneumonia, lobar pneumonia, community-acquired pneumonia, lung abscess, pleural empyema;
• infections of ENT organs, including otitis media, sinusitis, tonsillitis;
• infections of the genitourinary system: cystitis, pyelonephritis, bacterial prostatitis, urethritis, urethrocystitis, urogenital mycoplasmosis, acute orchiepididymitis; endometritis, endocervicitis and salpingoopiorit as part of a combined therapy; including sexually transmitted infections: urogenital chlamydia, syphilis in patients with intolerance to penicillins, uncomplicated gonorrhea (as an alternative therapy), inguinal granuloma, venereal lymphogranuloma;
• infections of the gastrointestinal tract and biliary tract (cholera, yersiniosis, cholecystitis, cholangitis, gastroenterocolitis, bacillary and amoebic dysentery, travelers' diarrhea);
• skin and soft tissue infections (including wound infections after animal bites), severe acne (as part of combination therapy);
• other diseases: yaws, legionellosis, chlamydia of various localization (including prostatitis and proctitis), rickettsiosis, Q fever, Rocky Mountain spotted fever, typhus (including typhus, tick-borne relapsing), Lyme disease (I st. - erythema migrans), tularemia, plague, actinomycosis, malaria; infectious eye diseases, as part of combination therapy - trachoma; leptospirosis, psittacosis, ornithosis, anthrax (including pulmonary form), bartonellosis, granulocytic ehrlichiosis; whooping cough, brucellosis, osteomyelitis; sepsis, subacute septic endocarditis, peritonitis;
• prevention of postoperative purulent complications; malaria caused Plasmodium falciparum, with short-term travel (less than 4 months) in the territory where strains resistant to chloroquine and / or pyrimethamine-sulfadoxine are common.

Contraindications

• hypersensitivity to tetracyclines
• pregnancy
• lactation
• age up to 8 years
• severe liver and/or kidney dysfunction
• porphyria

Dosage and administration
Usually the duration of treatment is 5-10 days. Tablets are dissolved in a small amount of water (about 20 ml) to form a suspension, which can also be swallowed whole, divided into parts or chewed with water. Preferably taken with food.

Adults and children over 8 years of age weighing more than 50 kg prescribe 200 mg in 1-2 doses on the first day of treatment, then 100 mg daily. In cases of severe infections, Unidox is prescribed at a dose of 200 mg daily for the duration of treatment.
Children 8-12 years old weighing less than 50 kg the average daily dose is 4 mg / kg on the first day, then 2 mg / kg per day (in 1-2 doses). In cases of severe infections, Unidox is prescribed at a dose of 4 mg / kg daily during the entire treatment.

Features of dosing for certain diseases
With an infection caused by S.pyogenes, Unidox is taken for at least 10 days.
For uncomplicated gonorrhea (excluding anorectal infections in men):
Adults are prescribed 100 mg twice a day until a complete cure (on average within 7 days), or 600 mg is prescribed for one day - 300 mg in 2 divided doses (second dose 1 hour after the first).

For primary syphilis, 100 mg twice a day for 14 days is prescribed; for secondary syphilis, 100 mg twice a day for 28 days.

For uncomplicated urogenital infections caused by Chlamydia trachomatis, cervicitis, non-gonococcal urethritis caused by Ureaplasma urealiticum, 100 mg is prescribed 2 times a day for 7 days.

For acne, 100 mg / day is prescribed, the course of treatment is 6-12 weeks.

Malaria (prevention): 100 mg 1 time per day for 1-2 days before the trip, then daily during the trip and within 4 weeks after returning; children over 8 years of age, 2 mg / kg 1 time per day.

Diarrhea "travelers" (prevention) - 200 mg on the first day of the trip (for 1 dose or 100 mg 2 times a day), then 100 mg 1 time per day during the entire stay in the region (no more than 3 weeks).

Treatment of leptospirosis - 100 mg orally 2 times a day for 7 days; prevention of leptospirosis - 200 mg once a week during a stay in a disadvantaged area and 200 mg at the end of the trip.

In order to prevent infections during medical abortion, 100 mg is prescribed 1 hour before and 200 mg after the intervention.

The maximum daily dose for adults is up to 300 mg / day or up to 600 mg / day for 5 days in severe gonococcal infections. For children over 8 years old weighing more than 50 kg - up to 200 mg, for children 8-12 years old weighing less than 50 kg - 4 mg / kg daily during the entire treatment.

In the presence of renal (creatinine clearance less than 60 ml / min) and / or liver failure, a decrease in the daily dose of doxycycline is required, since in this case it gradually accumulates in the body (risk of hepatotoxicity).

Side effects
From the gastrointestinal tract:
anorexia, nausea, vomiting, dysphagia, diarrhea, enterocolitis, pseudomembranous colitis.

Dermatological and allergic reactions:
urticaria, photosensitivity, angioedema, anaphylactic reactions, exacerbation of systemic lupus erythematosus, maculopapular and erythematous rash, pericarditis, exfoliative dermatitis.

From the side of the liver:
liver damage (with prolonged use of the drug or in patients with renal or hepatic insufficiency).

From the side of the kidneys: an increase in residual urea nitrogen due to the antianabolic effect of the drug.

From the hematopoietic system:
hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia, decreased prothrombin activity.

From the nervous system:
benign increase in intracranial pressure (anorexia, vomiting, headache, swelling of the optic nerve), vestibular disorders (dizziness or unsteadiness).

From the side of the thyroid gland:
in patients who have received doxycycline for a long time, reversible dark brown staining of the thyroid tissue is possible.

From the teeth and bones:
doxycycline slows down osteogenesis, disrupts the normal development of teeth in children (the color of the teeth changes irreversibly, enamel hypoplasia develops).

Other:
candidiasis (stomatitis, glossitis, proctitis, vaginitis) as a manifestation of superinfection.

Overdose
Symptoms:
Increased adverse reactions caused by liver damage - vomiting, fever, jaundice, azotemia, increased transaminase levels, increased prothrombin time.
Treatment:
Immediately after taking large doses, it is recommended to wash the stomach, drink plenty of water, and, if necessary, induce vomiting. Take activated charcoal and osmotic laxatives. Hemodialysis and peritoneal dialysis are not recommended due to low efficiency.

Drug Interactions
Antacids containing aluminum, magnesium, calcium, iron preparations, sodium bicarbonate, magnesium-containing laxatives reduce the absorption of doxycycline, so their use should be separated by an interval of 3 hours.
In connection with the suppression of intestinal microflora by doxycycline, the prothrombin index decreases, which requires dose adjustment of indirect anticoagulants.
When doxycycline is combined with bactericidal antibiotics that disrupt the synthesis of the cell wall (penicillins, cephalosporins), the effectiveness of the latter decreases.
Doxycycline reduces the reliability of contraception and increases the frequency of acyclic bleeding when taking estrogen-containing hormonal contraceptives.
Ethanol, barbiturates, rifampicin, carbamazepine, phenytoin and other stimulants of microsomal oxidation, accelerating the metabolism of doxycycline, reduce its concentration in blood plasma.
The simultaneous use of doxycycline and retinol increases intracranial pressure.

special instructions
There is a possibility of cross-resistance and hypersensitivity with other tetracycline drugs.
Tetracyclines can increase prothrombin time, the use of tetracyclines in patients with coagulopathy should be carefully monitored.
The antianabolic effect of tetracyclines can lead to an increase in the level of residual urea nitrogen in the blood. As a rule, this is not significant for patients with normal kidney function. However, in patients with renal insufficiency, there may be an increase in azotemia. The use of tetracyclines in patients with impaired renal function requires medical supervision.
With prolonged use of the drug, periodic monitoring of laboratory blood parameters, liver and kidney function is required.
In connection with the possible development of photodermatitis, it is necessary to limit insolation during treatment and for 4-5 days after it.
Prolonged use of the drug can cause dysbacteriosis and, as a result, the development of hypovitaminosis (especially B vitamins).
To prevent dyspeptic phenomena, it is recommended to take the drug during meals.

Features of influence on the ability to drive a car and operate mechanisms have not been researched.

Release form
Dispersible tablets 100 mg; 10 tablets in a PVC / aluminum foil blister. 1 blister with instructions for use in a cardboard box.

Storage conditions
At temperatures from 15 to 25 ºС.
Keep out of the reach of children!

Best before date
5 years.
Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies
On prescription.

Produced:

Elisabethof 19, Leiderdorp

Packaged and/or packaged:
Astellas Pharma Europ B.V., The Netherlands
or ZAO ORTAT, Russia

Consumer claims should be sent to:
Moscow representative office of Astellas Pharma Europe B.V., Netherlands:
109147 Moscow, Marksistskaya st. 16
"Mosalarko Plaza-1" business center, floor 3